InvestMacro

By CountingPips.com – Receive our weekly COT Reports by Email

Here are the latest links to our coverage of the Commitment of Traders data changes.

This week in the COT data, currency speculators once again added to their US Dollar Index bullish positions for a third straight week and pushed the USD position to the highest level in 26 weeks.

Speculators increased their Japanese yen bullish bets this week and the JPY position has now improved by a total of +132,190 contracts following this year’s low-point on April 30th.

The euro speculator bets went more bearish for a 3rd straight week while the British pound sterling bets fell to -92,233 contracts and remains the most bearish currency for speculators.

Precious metals speculators sharply retreated from their Gold bullish positions just one week after pushing their bets above the +300,000 net contract level for the first time in just about 3 years.

Silver speculator bets slipped slightly this week after rising for the previous 3 weeks. Silver positions, like gold, have accelerated quickly and have gone from a total of -8,443 contracts to +60,231 contracts in just 15 weeks.

Copper speculators retreated sharply from their bearish positions this week after recording a new all-time record high bearish position for two weeks in a row.

VIX speculators are starting to build back their bearish positions – sharply adding to their bearish bets for a second straight week and by the most in 25 weeks.

The 10-Year Bond speculators cut back on their bearish bets this week for the 3rd time out of the past 4 weeks. Specs continue to remain in a strong bearish standing but this has now fallen to a 9-week low.

Lastly, the WTI Crude Oil speculators boosted their bullish bets by the most in 25 weeks this week. Crude bets had remained consistently under the +400,000 contract level before this week’s jump.

Speculators add to US Dollar Index, Japanese yen bullish bets. Euro, GBP bets fall

Large currency speculators increased their net positions in the US Dollar Index futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday. See full article.

WTI Crude Oil Speculators sharply lifted their bullish bets to 15-week high

The large speculator contracts of WTI crude futures totaled a net position of 428,205 contracts, according to the latest data this week. This was a change of 44,048 contracts from the previous weekly total. See full article.

10-Year Note Speculators decreased their bearish bets for 3rd time in 4 weeks

Large speculator contracts of the 10-Year Bond futures totaled a net position of -300,433 contracts, according to the latest data this week. This was a change of 77,434 contracts from the previous weekly total. See full article.

Gold Speculators sharply pared their bullish bets after close to 3-year high

Large precious metals speculator contracts of the Gold futures totaled a net position of 269,725 contracts, according to the latest data this week. This was a change of -30,822 contracts from the previous weekly total. See full article.

VIX Speculators sharply boosted their bearish bets, up for 2nd week

Large stock market volatility speculator contracts of the VIX futures totaled a net position of -93,429 contracts, according to the latest data this week. This was a change of -26,787 contracts from the previous weekly total. See full article.

Silver Speculators edged their bullish bets lower for 1st time in 4 weeks

Large precious metals speculator contracts of the silver futures totaled a net position of 60,231 contracts, according to the latest data this week. This was a change of -1,894 contracts from the previous weekly total. See full article.

Copper Speculators sharply cut back on bearish bets after record high

Metals speculator contracts of the copper futures totaled a net position of -41,186 contracts, according to the latest data this week. This was a change of 17,655 contracts from the previous weekly total. See full article.

Article By CountingPips.com – Receive our weekly COT Reports by Email

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

US Dollar Index Speculator Positions

Large currency speculators continued to raise their net bullish positions in the US Dollar Index futures markets this week while speculators also boosted their Japanese yen positions, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of US Dollar Index futures, traded by large speculators and hedge funds, totaled a net position of 32,032 contracts in the data reported through Tuesday September 10th. This was a weekly gain of 296 contracts from the previous week which had a total of 31,736 net contracts.

This week’s net position was the result of the gross bullish position (longs) dropping by -4,927 contracts (to a weekly total of 49,483 contracts) compared to the gross bearish position (shorts) which saw a decrease by -5,223 contracts on the week (to a total of 17,451 contracts).

US Dollar Index bullish bets edged higher for a third straight week and have now risen in nine out of the past eleven weeks. This week’s gain brings the USD Index position to the most bullish level in twenty-six weeks dating back to the middle of March.

Individual Currencies Data this week:

In the all major currency contracts data, the currencies that saw improving speculator positions this week were the US dollar index (296 weekly change in contracts), Japanese yen (4,909 contracts), Swiss franc (2,947 contracts), Canadian dollar (6,174 contracts), Australian dollar (6,304 contracts), New Zealand dollar (886 contracts) and the Mexican peso (3,846 contracts).

The currencies whose speculative bets declined this week were the euro (-706 weekly change in contracts) and the British pound sterling (-7,274 contracts).

Notables for the week:

Japanese yen bullish bets rose this week after a down week and are now higher for the seventh time in the past eight weeks. Sentiment for the JPY has turned for the positive after reaching the low of the year on April 30th at a total of -99,599 net contracts. Since that low, positions have improved by a total of +132,190 contracts and turned bullish on August 6th.

Euro speculators added to the existing bearish positions for a third straight week this week. The euro position is now at the most bearish level in the past six weeks but it is not all bad news as the bearish position is only half of what it was in late May (-101,102 net contracts).

British pound sterling positions went more bearish this week after seeing improvements (less bearish) in the previous four weeks. This week’s net level (-92,233 contracts) remains close to the cycle’s bearish high (-102,702 net contracts) that was reached on August 6th and keeps the pound sterling as easily the most bearish (among speculators) of the major currencies.

Chart: Current Strength of Each Currency compared to their 3-Year Range

See the table and individual currency charts below.

Table of Large Speculator Levels & Weekly Changes:

This latest COT data is through Tuesday and shows a quick view of how large speculators or non-commercials (for-profit traders) were positioned in the futures markets. All currency positions are in direct relation to the US dollar where, for example, a bet for the euro is a bet that the euro will rise versus the dollar while a bet against the euro will be a bet that the dollar will gain versus the euro.

Weekly Charts: Large Trader Weekly Positions vs Price

EuroFX:

The Euro large speculator standing this week came in at a net position of -49,842 contracts in the data reported through Tuesday. This was a weekly fall of -706 contracts from the previous week which had a total of -49,136 net contracts.

British Pound Sterling:

The large British pound sterling speculator level totaled a net position of -92,233 contracts in the data reported this week. This was a weekly fall of -7,274 contracts from the previous week which had a total of -84,959 net contracts.

Japanese Yen:

Large Japanese yen speculators totaled a net position of 32,591 contracts in this week’s data. This was a weekly rise of 4,909 contracts from the previous week which had a total of 27,682 net contracts.

Swiss Franc:

The Swiss franc speculator standing this week reached a net position of -2,892 contracts in the data through Tuesday. This was a weekly advance of 2,947 contracts from the previous week which had a total of -5,839 net contracts.

Canadian Dollar:

Canadian dollar speculators reached a net position of 11,523 contracts this week. This was a increase of 6,174 contracts from the previous week which had a total of 5,349 net contracts.

Australian Dollar:

The large speculator positions in Australian dollar futures was a net position of -53,014 contracts this week in the data ending Tuesday. This was a weekly rise of 6,304 contracts from the previous week which had a total of -59,318 net contracts.

New Zealand Dollar:

The New Zealand dollar speculative standing resulted in a net position of -29,790 contracts this week in the latest COT data. This was a weekly gain of 886 contracts from the previous week which had a total of -30,676 net contracts.

Mexican Peso:

Mexican peso speculators came in at a net position of 95,637 contracts this week. This was a weekly rise of 3,846 contracts from the previous week which had a total of 91,791 net contracts.

Article By CountingPips.com – Receive our weekly COT Reports by Email

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

WTI Crude Oil Non-Commercial Speculator Positions:

Large energy speculators boosted their bullish net positions in the WTI Crude Oil futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of WTI Crude Oil futures, traded by large speculators and hedge funds, totaled a net position of 428,205 contracts in the data reported through Tuesday September 10th. This was a weekly lift of 44,048 net contracts from the previous week which had a total of 384,157 net contracts.

The week’s net position was the result of the gross bullish position (longs) going up by 18,639 contracts (to a weekly total of 527,579 contracts) while the gross bearish position (shorts) dropped by -25,409 contracts for the week (to a total of 99,374 contracts).

WTI crude speculators added to their bullish bets by the largest one-week amount in the past twenty-five weeks and pushed their positions to the highest level in fifteen weeks. The crude speculative position had been consistently creeping lower throughout the summer as the overall net position had been under the +400,000 contract level in eleven out of the thirteen weeks preceding this week’s gain.

WTI Crude Oil Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of -424,188 contracts on the week. This was a weekly shortfall of -42,069 contracts from the total net of -382,119 contracts reported the previous week.

WTI Crude Oil Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the WTI Crude Oil Futures (Front Month) closed at approximately $57.40 which was an advance of $3.46 from the previous close of $53.94, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

10-Year Note Non-Commercial Speculator Positions:

Large bond speculators reduced their bearish net positions in the 10-Year Note futures markets again this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of 10-Year Note futures, traded by large speculators and hedge funds, totaled a net position of -300,433 contracts in the data reported through Tuesday September 10th. This was a weekly change of 77,434 net contracts from the previous week which had a total of -377,867 net contracts.

The week’s net position was the result of the gross bullish position (longs) increasing by 35,357 contracts (to a weekly total of 623,170 contracts) while the gross bearish position (shorts) fell by -42,077 contracts for the week (to a total of 923,603 contracts).

10-Year Note speculators decreased their bearish bets for the third time out of the past four weeks and pulled their overall bearish net position to the lowest standing in nine weeks. Overall, speculators have continued to maintain a bearish stance despite the strength and rise of the 10-year prices. This cycle has been markedly different from the past where the speculators were reliable trend-followers and correlated with the 10-year price (see chart below).

10-Year Note Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of 243,084 contracts on the week. This was a weekly drop of -105,526 contracts from the total net of 348,610 contracts reported the previous week.

10-Year Note Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the 10-Year Note Futures (Front Month) closed at approximately $130.15 which was a fall of $-1.96 from the previous close of $132.12, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

Gold Non-Commercial Speculator Positions:

Large precious metals speculators sharply cut back on their bullish net positions in the Gold futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of Gold futures, traded by large speculators and hedge funds, totaled a net position of 269,725 contracts in the data reported through Tuesday September 10th. This was a weekly reduction of -30,822 net contracts from the previous week which had a total of 300,547 net contracts.

The week’s net position was the result of the gross bullish position (longs) dropping by -31,271 contracts (to a weekly total of 334,114 contracts) while the gross bearish position (shorts) fell by just -449 contracts for the week (to a total of 64,389 contracts).

Gold bullish bets dropped this week by the largest amount in sixteen weeks after rising above the +300,000 net contract level last week. That was the first time bullish bets had been above that level since September 6th of 2016, almost exactly three years prior. Gold bullish bets have been on a remarkable run since this year’s low-point on April 23rd when the net position stood at just +37,395 contracts. Since that time, just twenty-one weeks ago, bullish positions have exploded higher by a total of +232,330 net contracts and have risen in fourteen out of the twenty weeks following the low.

Gold Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of -305,611 contracts on the week. This was a weekly rise of 32,130 contracts from the total net of -337,741 contracts reported the previous week.

Gold Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the Gold Futures (Front Month) closed at approximately $1499.20 which was a decrease of $-56.70 from the previous close of $1555.90, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

VIX Non-Commercial Speculator Positions:

Large volatility speculators strongly added their bearish net positions in the VIX futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of VIX futures, traded by large speculators and hedge funds, totaled a net position of -93,429 contracts in the data reported through Tuesday September 10th. This was a weekly lowering of -26,787 net contracts from the previous week which had a total of -66,642 net contracts.

The week’s net position was the result of the gross bullish position (longs) falling by -16,361 contracts (to a weekly total of 96,684 contracts) while the gross bearish position (shorts) saw a gain by 10,426 contracts for the week (to a total of 190,113 contracts).

VIX speculative bearish positions pushed higher once again this week following a modest gain last week (-9,489 contracts). This week’s increase by more than -26,000 contracts is the largest one-week bearish rise in the past twenty-five weeks and puts the overall bearish level back near the -100,000 contract standing. VIX speculator bets hit a record high bearish position earlier this year in late April (-180,359 contracts) before pulling back. Bearish bets also looked to be heading that way again in late July (-144,314 contracts) before the risk-off themes of August prompted traders to sharply flee their bearish positions. The recent calming in the markets may see traders build their bearish positions back above the -100,000 contract level in coming weeks.

VIX Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of 102,041 contracts on the week. This was a weekly gain of 30,167 contracts from the total net of 71,874 contracts reported the previous week.

VIX Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the VIX Futures (Front Month) closed at approximately $17.67 which was a fall of $-1.85 from the previous close of $19.52, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

Silver Non-Commercial Speculator Positions:

Large precious metals speculators slightly trimmed their bullish net positions in the Silver futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of Silver futures, traded by large speculators and hedge funds, totaled a net position of 60,231 contracts in the data reported through Tuesday September 10th. This was a weekly reduction of -1,894 net contracts from the previous week which had a total of 62,125 net contracts.

The week’s net position was the result of the gross bullish position (longs) falling by -4,564 contracts (to a weekly total of 100,413 contracts) while the gross bearish position (shorts) declined by a lesser amount of -2,670 contracts for the week (to a total of 40,182 contracts).

The Silver speculative bets dipped this week following three straight weeks of gains that had added over +22,000 contracts to the overall net bullish position. Speculator sentiment has risen for ten out of the past fifteen weeks that has taken the net position from a total of -8,443 contracts on June 4th to a total of +60,231 contracts as of this week. Despite the small pullback, this week marked the first time since November of 2017 that the net position has been above +60,000 contracts for two straight weeks.

Silver Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of -84,768 contracts on the week. This was a weekly decrease of -90 contracts from the total net of -84,678 contracts reported the previous week.

Silver Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the Silver Futures (Front Month) closed at approximately $1818.60 which was a loss of $-105.10 from the previous close of $1923.70, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

September 14th – By CountingPips.com – Receive our weekly COT Reports by Email

Copper Non-Commercial Speculator Positions:

Large precious metals speculators strongly reduced their bearish net positions in the Copper futures markets this week, according to the latest Commitment of Traders (COT) data released by the Commodity Futures Trading Commission (CFTC) on Friday.

The non-commercial futures contracts of Copper futures, traded by large speculators and hedge funds, totaled a net position of -41,186 contracts in the data reported through Tuesday September 10th. This was a weekly change of 17,655 net contracts from the previous week which had a total of -58,841 net contracts.

The week’s net position was the result of the gross bullish position (longs) increasing by 1,086 contracts (to a weekly total of 77,185 contracts) while the gross bearish position (shorts) dropped by -16,569 contracts for the week (to a total of 118,371 contracts).

Copper speculators cut back on their bearish positions by the largest one-week amount in the past twenty-eight weeks. The speculative position had risen to a new all-time record high bearish position for two consecutive weeks previously. Overall, the copper standing has now been in bearish territory for only twenty straight weeks but the strength of bearish sentiment accelerated quickly and resulted in record levels before this week’s turnaround.

Copper Commercial Positions:

The commercial traders position, hedgers or traders engaged in buying and selling for business purposes, totaled a net position of 40,421 contracts on the week. This was a weekly decline of -18,576 contracts from the total net of 58,997 contracts reported the previous week.

Copper Futures:

Over the same weekly reporting time-frame, from Tuesday to Tuesday, the Copper Futures (Front Month) closed at approximately $262.80 which was an increase of $10.00 from the previous close of $252.80, according to unofficial market data.

*COT Report: The COT data, released weekly to the public each Friday, is updated through the most recent Tuesday (data is 3 days old) and shows a quick view of how large speculators or non-commercials (for-profit traders) as well as the commercial traders (hedgers & traders for business purposes) were positioned in the futures markets.

The CFTC categorizes trader positions according to commercial hedgers (traders who use futures contracts for hedging as part of the business), non-commercials (large traders who speculate to realize trading profits) and nonreportable traders (usually small traders/speculators).

Find CFTC criteria here: (http://www.cftc.gov/MarketReports/CommitmentsofTraders/ExplanatoryNotes/index.htm).

Article By CountingPips.com – Receive our weekly COT Reports by Email

By The Life Science Report

Source: Streetwise Reports   09/12/2019

Shares of Moderna Inc. traded up double-digits today as the firm announced results from its Phase 1 CMV Vaccine Study as well as its Phase 1 data for mRNA-1944 encoding for antibody against the chikungunya virus.

This morning clinical-stage biotechnology company Moderna Inc. (MRNA:NASDAQ), which states it is pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines, announced positive data from the three-month interim analysis of safety and immunogenicity of the Phase 1 study of its investigational cytomegalovirus (CMV) vaccine (mRNA-1647).

Based on these data, the firm advised that it is advancing mRNA-1647 to a dose-confirmation Phase 2 study in the near term. Preparation has also begun for a pivotal Phase 3 study designed to evaluate the efficacy of mRNA-1647 against primary CMV infection. The firm indicates that mRNA-1647 is a vaccine combining six mRNAs in a single vial, which encode for two antigens on the surface of CMV: five mRNAs encoding the subunits that form the membrane-bound pentamer complex and one mRNA encoding the full-length membrane-bound glycoprotein B (gB).

Tal Zaks, M.D., Ph.D., chief medical officer at Moderna commented, “I am very encouraged by the ability of mRNA-1647 to induce high levels of durable immune responses that can reach or exceed the levels generated by natural CMV infection…We recognize there is an urgent need for a preventative vaccine against congenital CMV and will be advancing mRNA-1647 into a Phase 2 study in the near term to confirm the appropriate dose, while we plan for a pivotal Phase 3 study.”

Sallie Permar, M.D., Ph.D., associate dean of physician scientist development and professor of pediatrics, immunology, and molecular genetics and microbiology at Duke Medical School, added, “Cytomegalovirus is the leading infectious cause of birth defects, and there is a great need for a vaccine that blocks transmission of the virus from the mother to the fetus…These interim data are exciting because mRNA-1647 has shown the ability to induce immune responses in seronegative individuals that are greater than what is seen in those naturally infected with CMV, which is important in that natural immunity is not completely protective against congenital CMV transmission.”

The Phase 1 study, which has completed enrollment, is evaluating the safety and immunogenicity of mRNA-1647 in 169 healthy adult volunteers. The study population includes those who were naïve to CMV infection (CMV-seronegative) and those who had previously been infected by CMV (CMV-seropositive). A safety analysis indicated that the vaccine was generally well tolerated and there were no vaccine-related serious adverse events.

CMV is a common pathogen and member of the herpesvirus family. Congenital CMV infection results when infected mothers transmit the virus to their unborn child, and it is the leading infectious cause of birth defects in the U.S., with approximately 25,000 newborns in the U.S. infected every year. There is currently no approved vaccine for the prevention of CMV infection.

The company also today announced positive data in the first analysis of safety and activity in its Phase 1 study evaluating escalating doses of mRNA-1944 administered via intravenous infusion in healthy adults. mRNA-1944 encodes for an antibody (CHKV-24) with activity against chikungunya virus.

The data from the study shows that at all three dose levels, the administration of mRNA-1944 led to detectable levels of CHKV-24 antibody in all participants, ranging from 1 µg/mL to 14 µg/mL. The firm states that these results mark the first systemic mRNA therapeutic to show production of a secreted protein in humans. mRNA-1944 is being developed with financial support from the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense. mRNA-1944 is the first development candidate from the company’s systemic therapeutics modality to start clinical testing and utilizes the same lipid nanoparticle (LNP) formulation as the company’s rare disease program for methylmalonic acidemia (mRNA-3704). A total of 22 healthy adults have been enrolled in the study to date.

Dr. Zaks advised, “These Phase 1 data represent a significant scientific breakthrough: this study shows for the first time the ability to generate therapeutic levels of a complex protein in humans through systemic administration of an mRNA, essentially instructing the body to make its own medicines.”

Moderna’s CEO Stéphane Bancel stated, “These data represent another critical milestone for the validation of Moderna’s mRNA platform in humans…This is the fifth modality for which we have shown translation from preclinical research to humans and the first demonstration of mRNA as a systemic therapeutic capable of creating high levels of protein at a well-tolerated dose. We believe these results further validate our approach, the scientific platform we have built and the potential of mRNA to become a new class of medicines. We look forward to learning from the ongoing Phase 1/2 study of mRNA-3704 for methylmalonic acidemia, the first of our rare disease programs to enter the clinic, as it utilizes the same technology demonstrated in this chikungunya study.”

Chikungunya is a mosquito-borne virus that poses a significant public health problem in tropical and subtropical regions. The disease is characterized by an acute onset of fever, rash, muscle pain and sometimes debilitating pain in multiple joints. There are no vaccines approved to prevent chikungunya infection or disease.

Moderna Inc. is a clinical stage biotechnology company headquartered in Cambridge, Mass., engaged in transformative medicines based on messenger ribonucleic acid (mRNA). It is pursuing mRNA science to minimize the undesirable activation of the immune system by mRNA and to maximize the potency of mRNA once in the target cells. The company has a diverse development pipeline of 22 programs with multiple clinical studies underway. Its therapeutics and vaccine development programs span infectious diseases, oncology, cardiovascular diseases and rare genetic diseases. The company currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc. and the Defense Advanced Research Projects Agency.

MRNA share opened today at $17.34 (+$1.42, +8.92%) over yesterday’s $15.92 closing price. The stock has traded today between $16.23 and $18.46/share and at present is trading at $16.84 (+$0.92, +5.78%).

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports’ terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professional for medical advice.

( Companies Mentioned: MRNA:NASDAQ,
)

By The Gold Report

Source: Streetwise Reports   09/12/2019

Bob Moriarty of 321 Gold discusses what the Daily Sentiment Indicator is saying about the precious metals markets.

Once again the DSI (Daily Sentiment Indicator) made an accurate call on a major top in gold and silver. The DSI reached nosebleed territory for gold about four weeks ago suggesting the metals were nearing shoal waters. Silver and platinum got stupid a week ago and I suggested a correction would be timely.

Investors should remember that when someone writes a recommendation or makes a comment no matter whom it is, they are expressing an opinion. I don’t give a damn how many facts or figures someone uses, it’s an opinion. But in my experience the use of the Daily Sentiment Indicator has proven very accurate calling the top in the stock market in 2018 and the bottom in late December. Now, once again it has identified a tradable top.

People got way too bullish on the metals. All I saw and heard was a ton of people talking about how high gold and silver were going to go. The number of outstanding contracts hit a record high. It always does at tops, that’s what makes it a top no matter how long it lasts. The weak hands buy at tops and sell at bottoms. They also are the biggest users of margin so once a decline gets serious they panic and start a cascading decline.

I am on record calling for a top in the overall market in September leading to a major crash starting in October. It’s just an opinion but I am getting my gas mask on and fixing to head to the nearest bunker.

Now many writers are talking about some minor correction before gold and silver once again bolt for the running rabbit. I don’t think so. With the record bullishness, you need both time and price to scare hell out of the weak hands and for sure that hasn’t happened.

When the DSI for gold and silver and platinum break under 10 you can put your life jacket back on and jump in. If the markets follow the traditional calendar, that will be about mid December.

In a different vein, I want to thank the hundreds of people who wrote to me expressing their sorrow at the news of the death of my wife. We knew she was ill, she was tired and wanted out but still when it happened it was the biggest shock of my life. I miss her so.

I’ve learned a lot and while it may seem callous of me to run the website with tears on my face, I need something to make it worth breathing. Now I realize that life is a teeter-totter. The opposite side of deep love is incredible pain. I loved Barbara deeply and I mourn her greatly. Thank you if you were one of those kind enough to share your thoughts.

Bob and Barb Moriarty brought 321gold.com to the Internet almost 16 years ago. They later added 321energy.com to cover oil, natural gas, gasoline, coal, solar, wind and nuclear energy. Both sites feature articles, editorial opinions, pricing figures and updates on current events affecting both sectors. Previously, Moriarty was a Marine F-4B and O-1 pilot with more than 832 missions in Vietnam. He holds 14 international aviation records.

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Disclosure:
1) Statements and opinions expressed are the opinions of Bob Moriarty and not of Streetwise Reports or its officers. The auther is wholly responsible for the validity of the statements. Streetwise Reports was not involved in any aspect of the article preparation. The author was not paid by Streetwise Reports LLC for this article. Streetwise Reports was not paid by the author to publish or syndicate this article.
2) This article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports’ terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
3) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.